The two sides sit level on 11 points, but dangerously close to the relegation zone, so no doubt they could both use maximum points from the clash at Renzo Barbera.
Palermo failed to build on promising showings against Bologna and Inter as they were comfortably beaten by in-form Napoli in midweek.
Meanwhile, Empoli have shown plenty of improvement, winning last two fixtures while also holding very good Sampdoria side to a 1-1 draw at Marassi.
Coach Beppe Iachini has no fresh injury worries, but Uros Djurdjevic, Michel Morganella and Francesco Bolzoni remain on the sidelines. The likes of Roberto Vitiello and Gaston Burgman are pushing for starting places.
Probable starting line-up (3-5-1-1): Sorrentino – Vitiello, Gonzalez, Andjelkovic – Rispoli, Hiljemark, Maresca, Rigoni, Lazaar – Vazquez – Gilardino.
Midfielder Assane Diousse misses out through suspension, whereas Levan Mchedlidze, Uros Cosic and Daniele Croce are all in the treatment room. Marko Livaja should replace Massimo Maccarone up front, whereas Leandro Paredes is likely to be recalled to the starting line-up.
Probable starting line-up (4-3-1-2): Skorupski – Laurini, Tonelli, Costa, Mario Rui – Zielinski, Maiello, Paredes – Saponara – Pucciarelli, Livaja.
The two teams boast an identical record after ten league games (W3 D2 L5 11:15)
At least one team have failed to score in six of last seven Serie A meetings between the two sides
Empoli boast a 6-1-3 record in last ten matches against Palermo
Palermo are winless in last four home matches (D2 L2) and conceded eight goals in the process
Palermo scored just one goal in the first periods of last five games
Empoli failed to score a single goal in the first half of last four away matches
Palermo vs Empoli prediction
With both teams lacking confidence at the moment and not exactly firing on all cylinders, we are unlikely to see too many goals at Stadio Renzo Barbera. With six of their previous Serie A meetings seeing at least one team fail to score, we expect the trend to continue and suggest backing Both teams to score – no in this particular match.