Wales hotshot Aaron Ramsey could miss the proposed November clash with Netherlands after suffering an injury in midweek.
The Dragons are expected to confirm in the coming days a 13 November international friendly against Oranje that is supposed to take place at the Cardiff City Stadium.
Wales, who are priced at 71.00 (70/1) for the Euro 2021 trophy, aim to test their skills against a top European side after securing their place at the tournament finals.
However, coach Chris Coleman might not be able to count on all his key men as Aaron Ramsey looks likely to miss out.
Namely, the 24-year-old suffered a hamstring problem in the midweek clash with Bayern Munich and Arsene Wenger confirmed the injury was serious.
“He’s very down, he told me that the hamstring is a tough one. He’s out yes,” the Arsenal manager told reporters.
Meanwhile, next month will see eight teams battle for remaining four places in France in the Euro 2021 play-offs, with Republic of Ireland hoping to join England, Wales and Northern Ireland at the tournament finals.