Having somehow managed to escape defeat in Moscow, Manchester United desperately need to win this match or else they will be in real problems.
The Red Devils are not only winless in last four matches, but also failed to score in last three and clearly head into the game low on confidence.
CSKA Moscow, on the other hand, produced a very good performance in the first match and having since done well on domestic stage, they will fancy their chances of getting a positive result from Old Trafford.
Important midfielder Morgan Schneiderlin has missed training on Monday and he is rated doubtful for the clash with CSKA Moscow, with Michael Carrick ready to deputize if needed.
Memphis Depay and Phil Jones should be back in contention, but Antonio Valencia, Luke Shaw, James Wilson and Paddy McNair continue to miss out.
Probable starting line-up (4-2-3-1): De Gea – Darmian, Smalling, Jones, Rojo – Carrick, Schweinsteiger – Mata, Herrera, Martial – Rooney.
Bibras Natxo is slowly building match fitness after returning from injury and there is a chance he will be restored to the starting line-up.
Centre-back Vasili Berezutski is set to miss out through injury, but Alexei Berezutski should return to the side and key midfielder Roman Eremenko faces a fitness test.
Probable starting line-up (4-2-3-1): Akinfeev – Fernandes, A. Berezutski, Ignashevich, Schennikov – Dzagoev, Wernbloom – Tosic, Natxho, Musa – Doumbia.
-Manchester United boast a 1-2-0 record in three meetings with CSKA Moscow
-The last two matches between the sides ended in scoring draws (3-3, 1-1)
-Manchester United are unbeaten in last seven CL games at Old Trafford (W6 D1)
-The Red Devils only conceded one goal in last five matches at Old Trafford
-CSKA Moscow suffered 8 defeats in last 10 Champions League games on the road
-One of those two away wins were recorded over Manchester City in November 2014
Champions League Group B Standings
Manchester United vs CSKA Moscow prediction
With no goals scored in Manchester United’s last three games and plenty at stake at Old Trafford, chances are we will witness another low-scoring match. CSKA Moscow will be quite happy to sit back and wait for their opportunity on the break, and with the Red Devils far from dangerous up front, our advice is to back under 2.5 goals.